Steroid resistant basically represents a small sub group of those patients who are asthmatic and face difficulty in managing their asthma. Generally these patients fail to respond to high doses of bronchodilators and oral glucocorticosteroids. To have a clear diagnosis of steroid resistant asthma it is required to investigate different factors that might trigger an attack. These factors may be many like insufficient steroid that reach the airway and exposure to unknown or sensitizing agents.

Useful tests to differentiate these patients with steroid resistant asthma from those having serious asthma comes from their inability to perform reproducible forced expiratory manoeuvres, normal airway resistance and a concentration of histamine causing a 20% fall in the forced expiratory volume. In order to have a clinical diagnosis of steroid resistant asthma it is necessary to investigate the factors that could be operating to prevent the normal response to steroids. In some patients this type of asthma can be related due to factors existing that makes asthma even worse and hence demands greater requirement of steroids.

It is essential to have complete knowledge when it comes to steroid resistant asthma so as to get better treatment and taking in steroids will come to a halt to allow other anti-inflammatory drugs to be used by the patients to avoid further complications regarding steroid resistant asthma.